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KMID : 0380420180420010037
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Journal of Prventive Veterinary Medicine
2018 Volume.42 No. 1 p.37 ~ p.40
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Effects of reduced glutathione on stress and inflammatory response in Korean native calves vaccinated with foot-and-mouth disease vaccine
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Cha Chun-Nam
Chae Won-Seok
Park Eun-Kee
Yoo Chang-Yeul
Son Song-Ee
Kim Suk
Lee Hu-Jang
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Abstract
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This study evaluated the effect of reduced glutathione (GSH) for the reduction of stress and inflammatory response in calves inoculated with foot-and-mouth disease (FMD) vaccine. Twenty-five calves were divided into five groups of 5 calves. The negative control (NC) did not receive any vaccination or drug treatment. The positive control (PC), GSH-25, GSH-50 and GSH-100 were intramuscularly injected with GSH at concentrations of 0, 25, 50 and 100 mg / 10 kg body weight (BW), respectively, for 3 days after FMD vaccination. On day 3, 5 and 7 post-treatment, the serum cortisol and tumor necrosis factor- α (TNF-α) levels in GSH-50 and GSH-100 were significantly decreased compared with those in PC (p < 0.05). However, there was no significant difference in the serum cortisol and TNF-α levels between GSH-100 and NC 3 and 5 days post-treatment, and between GSH-50, GSH-100, and NC 7 days post-treatment. The results from this study suggest that treatment of 50 mg / 10 kg BW GSH for 3 days is useful for the reduction of stress and inflammatory response caused by FMD vaccination in calves.
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KEYWORD
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FMD vaccination, serum cortisol, serum TNF-α, reduced glutathione, korean native calf
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